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KMID : 0380620170490010090
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Korean Journal of Food Science and Technology
2017 Volume.49 No. 1 p.90 ~ p.96
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Effects of Pleurotus eryngii extract against inflammation in activated RAW 264.7 cells and UV-induced skin damage in mice
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Cho Byoung-Ok
Yin Hong-Hua
Lee Hyun-Seo
Chu Jung-Im
Jang Seon-Il
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Abstract
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The aim of this study was to investigate the anti-inflammatory and ultraviolet (UV)-protective effect of Pleurotus eryngii extract (PEE) in activated RAW 264.7 cells and UV-induced mouse skin damage. The results showed that PEE strongly inhibited the production of inflammatory mediators such as nitric oxide, interleukin (IL)-1β, and IL-6 at high concentrations in LPS-stimulated RAW 264.7 macrophages. In addition, PEE treatment suppressed erythema, melanin index, and epidermal thickness to a greater degree than ascorbic acid (AA) treatment in UV-irradiated mice. Finally, PEE treatment inhibited the infiltration of mast cell to a similar degree of AA treatment. Therefore, these results indicate that PEE could improve inflammation and skin damage in immune cells and UV-irradiated mice. This study may provide positive insights into PEE as a functional food and cosmetic ingredient for treatment of inflammation and skin damage.
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KEYWORD
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Pleurotus eryngii, anti-inflammation, UV-induced skin damage, protective effect
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